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While typically only Instants can be cast at Instant-speed, some MTG cards have activated abilities you can use

Creature Artifact - Myr Phyrexian Color tag templates(None) Silver Myr Creature Artifact - Myr Color tag templates(None) Ramp (CTRL to add secondary) Win Con Qty: 13 Price: $475.65 Hovermyr Creature Artifact - Myr Color tag templates(None) Ichorclaw Myr Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.) Whenever this creature becomes blocked, it gets +2/+2 until end of turn

Witchbane Orb Witchbane Orb is more of a situational you have hexproof card that can destroy all the curses attached to you when it enters

Example : During my upkeep, you activate Icy Manipulator, targeting my Island

If your opponent only has one creature, it doesn't really do anything